Knowledge Based 3D
 Medical Image Segmentation

Outline

The Goal of Segmentation

The Goal of Segmentation

Applications of Segmentation

Applications of Segmentation

Applications of Segmentation

Applications of Segmentation

Applications of Segmentation

Limitations of Manual Segmentation

The Automatic Segmentation Challenge

How to Segment? i.e. Issues in
Segmentation of Anatomy

How to Segment? i.e. Issues in
Segmentation of Anatomy

How to Segment? i.e. Issues in
Segmentation of Anatomy

How to Segment? i.e. Issues in
Segmentation of Anatomy

How to Segment? i.e. Issues in
Segmentation of Anatomy

How to Segment? i.e. Issues in
Segmentation of Anatomy

How to Segment? i.e. Issues in
Segmentation of Anatomy

Typical Pipeline for Segmentation of Brain MRI

Typical Pipeline for Segmentation of Brain MRI

Typical Pipeline for Segmentation of Brain MRI

Contributions of Thesis

Contributions of Thesis

Background to My Work

Expectation-Maximization

Expectation-Maximization (what?)

Expectation-Maximization (how?)

Expectation-Maximization (how exactly?)

Expectation-Maximization (how exactly?)

Expectation-Maximization

EM-Segmentation [Wells 1994]

Slide 32

Slide 33

EM-Segmentation [Wells 1994]

EM-Segmentation [Wells 1994]

EM-Segmentation [Wells 1994]

Situating My Work

The Gibbs Prior

EM-MF Segmentation: EM + Gibbs Prior

EM-MF Segmentation: Gibbs Prior on Classification

EM-MF Segmentation: Gibbs Prior on Classification

EM-MF Segmentation: Gibbs form of Posterior

EM-MF Segmentation: Gibbs form of Posterior

EM-MF Segmentation

EM-MF Segmentation

EM-MF Segmentation

EM-MF Segmentation

Mean-Field Approximation

Mean-Field Approximation to Posterior GRF

Summary of EM-MF Segmentation

EM-MF Results

Some Results

Some Results

More Results

Posterior Probabilities (EM)

Posterior Probabilities (EM-MF)

Results

Modeling Global Geometric Relationships between Structures

Modeling Global Geometric Relationships between Structures

Segmented Knee MRI

Motivation

Relative Geometric Prior Approach

Segment Primary Structures:
 Femur, Tibia

Status

Measure Geometric Relationship between Primary and Secondary Structures

Measure Geometric Relationship between Primary and Secondary Structures

Estimate of

Status

Use Relative Geometric Prior in EM Segmentation

Results: Segmentation of
Femoral & Tibial Cartilage

Relative Geometric Priors for Brain Tissue

Estimate

Resultant Segmentation

Posterior Probabilities

In Summary

Future Work

STOP

Class Conditional Density

Unified Bayesian Segmentation Method

Rest of Talk:

The Gibbs Prior

Components of EM Framework

Addition of Two Priors

Gibbs Model

Gibbs Model

Slide 86

Gibbs Model

Contributions of Thesis

Proposed MRI Segmentation Method

Proposed MRI Segmentation Method

Next

Computation of

Computation of

Computation of

The Gibbs Prior

The Mean-Field Solution

The Mean-Field Approximation

The Mean-Field Solution

EM-MF Summary